EFFECT OF HEMODIALYSIS ON TUMOR NECROSIS FACTOR ALPHA, CIRCULATING ADHESION MOLECULES ICA.M-1 AND VCAM-1 IN CHRONIC RENAL FAILURE
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The adhesion molecules ICAM-1 and VCAM-1 are regulated by proinflammatory cytokines and play an important role in the binding and activation of leucocytes in inflammatory diseases. They have been recently detected in serum of patients with chronic renal failure. This study measures the serum concentration of circulating adhesion molecules (cICAM-1 and cVCAM-1) and tumor necrosis factor alpha (TNF-a) before and after hemodialysis by ELISA technique. Before hemodialysis, both cICAM-1 and cVCAM-1 and TNFa levels were significantly elevated when compared to their levels after hemodialysis. Also before hemodialysis, their levels were significantly higher when compared to control group but after hemodialysis their levels in CRF patient were still elevated but not significant when compared to levels in control group. Moreover, the level of TNFa correlate with the level of cICAM-1 and cVCAM-1 before and after hemodialysis. This suggests that TNFa plays a role in expression of these adhesion molecules that may play a role in perpetuation for infection and inflammation that appear during the course of chronic renal failure. Also, this study shows the benificial effect of HD in decreasing the level of these nocuous adhesion molecules.