ROLE OF HELICOBACTER PYLORI IN BILE INDUCED INJURY TO GASTRIC ENDOTHELIUM
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Helicobacter Pylori (H.P.) has been found in gastric biopsy speciemens and linked to many diseases in the gastrointestinal tract (GIT). H.P. infection of the gastric mucosa is regarded as the major etiological agent in chronic diffuse, superficial gastritis and an important risk factor for the development of intestinal type of gastric carcinoma. Forty patients were included in this study (22 men and 18 women). Patients showed variant forms of endoscopic findings ranging from normal finding, to severe gastritis or duodenal ulcer. Twenty four patients (24/40) proved to be Helicobacter Pylori (HP) positive by rapid urease test (60%). Eighteen patients of them (18/24) were grain +ve (75%). Patients showed bile reflux with bile acid > 1 mmo1/1 were 24 (24/40) of total (60%) , 19 of them were HP positive by rapid urease test (79.1%) (p < 0.05). Sixteen patients of them were also Gram +ve for H.P. Those 16 patients which were DGR +ve, urease +ve and Gram +ve were subjected to treatment protocol of triple therapy for 2 weeks. Follow up was done after one month of the end of treatment. Ten patients with DGR showed marked reduction in bile acid concentration (< 1 mmol/L) while the rest showed no changes. Thirteen patients became H. pylori -ye. All DOR -ye patients became H. pylori -ye (p > 0.05). Histopathological examination of antral biopsy showed no inflammatory responses in 8 patients after eradication of H. pylori (n = 13) ( p < 0.05).