URIC ACID AND UREA CLEARANCE IN PATIENTS WITH CHRONIC HEPATITIS
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In cirrhotic patients without renal failure, salt retention could result from a decreased effective intravascular volume or could be a primary event leading to increased intravascular volume. Clearance of urea and uric acid depends on effective intravascular volume. This study was conducted on 25 patients with chronic hepatitis and 25 control subjects. The diagnosis of chronic hepatitis was confirmed by liver needle biopsy and elevated hepatic uansaminases. Exclusion of associated illnesses that affect urea and uric acid clearance or sodium excretion was emphasized. The result showed significant increase in the fractional excretion of uric acid in patients with chronic hepatitis as compared to the control group. This could be explained by selective tubulopatbhy for urea and uric acid by increased serum bilirubin, or increased effective vascular volume. Also, creatinine clearance in chronic hepatitis patients is lower than of control in spite of normal serum creatinine in chronic hepatitis patients and in the controls. This could be due to toxic glomerulopathy associated with chronic hepatitis. Also, we found normal serum uric acid in chronic hepatitis and in controls despite the increase in fractional excretion of uric acid in chronic hepatitis.