SERUM E- SELECTIN AS A PROGNOSTIC MARKER FOR DIABETES MELLITUS (TYPE II)
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Objectives: the purpose of this study was designed to evaluate the prognostic value of estimation of serum E-selectin in type II diabetic patients in a trial to correlate its level with their glycemic control and renal angiopathic complications. Backgrounds: Diabetes is characterized by many complications where the most important complications are the vascular ones in the form of microangiopathy and atherosclerotic changes such as nephropathy, retinopathy and neuropathy. The level of soluble form of E-selectin has been detected increased in sera of patients with type II diabetes mellitus where in type 2 DM there is increased endothelial dysfunction and chronic inflammation. Increased serum levels of cell adhesion molecules may be pathognomonic for diabetic microangiopathic changes in diabetic patients. Methods: This study was carried out on 45 patients with type 2 diabetes mellitus and 15 apparently healthy volunteers as a control group. The patients groups were divided into 3 groups according to the presence of protein in urine, group 1(15 patients) whose were normoalbumirturic, - group II (15 patients) whose urine revealed the presence of microalburninuric and group III (15 patients) whose urine showed macroalbuminuric. Serum soluble E- selectin was measured by quantitative sandwich enzyme imrnwioassay technique in all subjects.