Role of T Helper Cell Subsets in Active Systemic Lupus Erythematosus
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T helper cells subsets were studied in systemic lupus erythematosus (SLE), 18 patients with active SLE and 7 normal controls were subjected to basic investigations for SLE. Assay for Thl and Th2 was done by flow cytometry, significant reduction in C04 cells (P<0.01) compared to normal subjects with negative correlation to the disease activity index (A.I) and E.S.R (P<0.01) and no correlation with the complement C3 and C4 values. A consistent pattern of increased Th2 cells was coupled with decrease Thl in SLE patients. Th2 significantly increased in lupus patients (P<0.01) compared to controls with no correlation to AI, ESR or complement values (P>0.0S). T hl showed a significant decrease ( P<0.01) in I upus patients compared to normal controls with negative correlation to Al, ESR values (P<0.01) with no correlation to complement values. Th0 was significantly reduced (P<0.05) in SLE and did not show any correlation to either Ad, ESR or complement values. Thl/Th2 ratio showed highly significant decrease in lupus patients compared to controls (P<0.01). In SLE with nephritis C04, Thl cells and Thl/Th2 ratio were significantly reduced while Th2 and Th0 cells did not show any significant difference (P>0.01). Patient with corticosteroid therapy did not show any difference from those without such treatment. Thl/Th2 cell immunointervention may lead to effective management and prognosis in SLE.