PLASMA FIBRONECTIN IN TYPE I AND TYPE II DIABETIC PATIENTS AND ITS RELATION TO DIABETIC MACRO AND MICROANGIOPATHY
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This study included three groups of subjects: group (A) comprised 15 Insulin dependent diabetics, group (B) comprised 15 non-Insulin dependent diabetics and group (C) comprised 15 Normal healthy subjects (Control). All of them were subjected to a thorough history taking, clinical examination, fundus examination, plasma fibronectin level, fasting and two hour postprandial blood glucose. In conclusion we found that plasma fibronectin levels were higher in all diabetic groups with or without diabetic microangiopathy compared to control group (diabetics as whole, type - I diabetics, type II diabetics, diabetics with retinopathy and diabetics with diabetic foot ). Also plasma fibronectin levels were found higher in patients with diabetic retinopathy compared to those without retinopathy and higher in patients with diabetic foot compared to those without diabetic foot which agrees with the theory suggesting that plasma fibronectin is higher in diabetic microangiopathy. Plasma fibronectin concentration exhibited no significant correlation with fasting or two hour post prandial blood glucose or duration of diabetes. So fibronectin might be considered as indication of microvascular damage in diabetes mellitus and can represent an important approach in the study and prevention of diabetic microangiopathic disorders.