PITUITARY - TESTICULAR AXIS IN MEN WITH CHRONIC RENAL FAILURE (CRF) UNDERGOING REGULAR HEMODIALYSIS AND AFTER RENAL TRANSPLANTATION
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Pituitary testicular hormonal axis was studied in fifteen male patients with chronic renal failure and treated with regular hemodialysis, their ages ranged from 27 to 45 years; and in another ten male renal transplant recipients, they were studied 9-18 months after successful renal transplantation, their ages ranged from 27 to 47 years. Ten healthy adult males were chosen as control group, their ages ranged from 25 to 48 years. Assessment of follicle stimulating hormone (FSH), luteinzing hormone (LH), prolactin and testosterone levels in serum was done to all the studied groups. Also testosterone suppression test to luteinizing hormone was also done in a random group of dialyzed patients (7 patients). And we got the following results: (I) In the dialyzed group serum FSH, LH and prolactin levels were significantly increased (P < 0.001 to all) when compared to the normal control group, while serum testosterone level was significantly decreased (P < 0.001). (2) The testosterone suppression test in dialyzed group showed integrity of the pituitary-testicular hormonal axis in these patients. (3) In renal transplant group serum FSH, prolactin and testosterone levels were non significantly changed (P> 0.05 to all) when compared to the normal control group, while serum LH level was significantly decreased (P<0.001). From this study we can conclude the following: - In patients with CRF and undergoing regular hemodialysis, although there are some derangements in the levels of the hormones of the pituitary-testicular axis, this axis is still intact in these patients. - Successful renal transplantation can correct the hormonal pattern of the pituitary-testicular axis nearer to the normal.