STUDY OF URINARY TRANSFERRIN AND IRON EXCRETION IN INSULIN DEPENDENT DIABETES MELLITUS (IDDM) WITH VARIABLE DEGREES OF ALBUMINURIA
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This study included 60 insulin dependent diabetic male patients in 3 groups according to urinary albumin excretion . Group I with normal albuminuria (urine albumin < 30 mg/day), group II with microalbuminuria (urine albumin 30-300 mg/day) and group III with macroalbuminuria (urine albumin > 300mg/day). Each diabetic group included 20 cases and these groups were compared with control group comprised of 20 healthy subjects. The present work was undertaken to study urinary transferrin and iron in diabetic patients with varying amounts of alburninuria. The following were the results of this work: - There was significant increase (P < 0.05) in urinary transferrin and iron in all the studied diabetic groups compared to the normal control; and this increase occurrs early in the course of the diabetic renal disease. - The iron/transferrin ratio in urine was much higher than that in serum in all the diabetic groups. This means that iron is present in the urine in marked excess than its carrier transferrin. - There was significant positive correlation (P < 0.05) between urinary albumin and urinary transferrin in both the micro and macro albuminuric diabetic groups. - There was significant positive correlation (P < 0.05) between urinary albumin and urinary iron in all the diabetic groups. - There was significant positive correlation (P <0.05) between urinary iron and urinary transferrin in the nurcroalburninuric diabetic group. From this work we can conclude the following: - Transferrin which has the similar molecular size as albumin, its urinary excretion in excess as well as the excess excretion of urinary iron in diabetics may suggest the possibility of development of glomerular disease and nephropathy. glucose (Trinder, 1969). - Estimation of serum fructosamine (Johnson et al., 1982). - Urine analysis to exclude urinary tract infections. - Complete blood picture including haemoglobin %. - Estimation of serum and urinary creatinine (Husdan, 1968). - Estimation of serum albumin (Doumas, 1971). - Estimation of urinary albumin excretion/ 24 hours (Dona et al.,1987). - Estimation of serum and urinary transferrin (Utennann. 1989). - Estimation of serum and urinary iron by using atomic absorption spectrophotometer (Willis et al., 1960).