STUDY OF BLOOD COAGULATION AND FIBRINOLYSIS IN OBESE NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) PATIENTS
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Four groups of age and sex matched patients were studied: group 1:20 nondiabedc subjects with a body mass index (BM1) <25 kg/n? (lean control subjects); group 11:20 obese non diabetic subjects with a BMI>30 kg/n?; group 111:20 lean NIDDM subjects; and group 1V:20 obese NIDDM subjects. We determined: blood glucose, total cholesterol, triglycerides, HDL-Cholesterol, Apolipoprotein Al and B, insulin, Lipoprotein (a) (Lp(a)), fibrinogen, Factor VII, plasminogen, tissue plasminogen activator antigen(t-PA) (Ag) pre and post venous occlusion (VU) and plasminogen activator inhibitor (PA 1) activity pre and post VU (VU test is a physiological stress test used to study the fibrinolytic activity). In addition to metabolic abnormalities obese non diabetic subjects and lean and obese NIDDM patients displayed significantly higher levels of fibrinogen, Factor VII, plasminogen, PA1 pre and post VU and t-PA (Ag) pre VU and significantly lower levels of t-PA (Ag) post VU. Our findings demonstrate an impairment of the haemostatic and fibrinolytic mechanisms which may be a key role in the pathogenesis of atherosclerotic vascular complications in obesity and in NIDDM.