FIBRINOLYTIC ACTIVITY IN PATIENTS WITH DIABETIC NEPHROPATHY
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In the present work we studied the fibrinolytic activity in diabetic patients with and without nephropathy in a trial to find out the relation between the fibrinolytic activity and diabetic nephropathy. This study included 60 subjects classified into 3 groups: Group 1: 20 healthy normal controls. Group 2: 20 diabetic patients without nephropathy. Group 3: 20 diabetic patients with nephropathy. Fibrinolytic activity of blood includes: 1. Plasma fibrinogen level, b. Euglobulin clot lysis time, c. Serum fibrinogen / fibrin degradation products. The results of this work revealed: (1) The mean plasma fibrinogen levels was higher in diabetics than that of the control. Hyperfibrinogenameia was found in all cases with diabetic nephropathy and in 55% of diabetic without nephropathy, (2) The mean levels of serum fibrinogen / fibrin degradation products in the diabetics was significantly higher than that of the control group, (3) The mean euglobulin clot lysis time in the diabetics was longer than that of the control. The present study, showed that, fibrinolytic activity is depressed in diabetic patients, and more so in diabetics with nephropathy. Such decreased fibrinolytic activity favour hypercoagulable state and subsequent thromboembolic complications.