This study included forty subjects and they were classified
into: ten healthy normal subjects as controls, fifteen insulin
dependent diabetic patients without microalbuminuria and fifteen
insulin dependent diabetic patients with microalliuminuria. Patients
and controls were of approximately the same age. Serum total
cholesterol, HDLc, LIMe. VLDLe, triglycerides and LP (a) were
estimated in this study to find out the relation between lipoproteins
including LP (a) and diabetic nephrupathy. The mean serum
triglycerides and VI.Dlic were significantly higher (P<0.05) in
diabetic patients with microalbuminuria compared to diabetic
patients without microalbuminuria or to control group. The mean
serum LP (a) level in diabetics without microalbuminuria was
significantly higher (P<0.05) than that of the control group.
Moreover, the mean serum 1.11 (a) level in diabetics with
microalbuminuria. was significantly higher than the, controls
(P<0.05) or diabetics without microalbuminuria (P<0.05). There
was significant positive correlation between serum LP (a) and
fasting scrum glucose, postprandial glucose, total cholesterol 'and
LDLc in diabetics with and without microalbuminuria. Elevated
levels of LP (a) can be used as a. marker for the development of
. diabetic nephropathy as it increases in patients with IDDM without
'microalbuminuria more than the controls. Moreover, higher levels
were detected in microalbuminuric patients inspite of good control
of the diabetic state. |
