A STUDY OF ERYTHROCYTE MEMBRANE LIPID PEROXIDATION IN DIABETES MELLITUS
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In this study membrane lipid peroxidation in erythrocytes fifteen diabetic patients and its correlation with plasma glucose was studied. Diabetic patients were eight males and seven females. Their ages ranged 20-45, with a mean value of 30 ± 3.5 years. Al! patients in this study were insulin dependent diabetics, except 2 who had non insulin dependent diabetes. Another fifteen healthy subjects volunteered as controls. Their ages ranged 23-46 , with a mean value of 29± 4.1 years. Lipid peroxidation was estimated by quantitating malondialdehyde (NIDA), an end product of lipid peroxidation. Erythrocytes of diabetics showed a significantly higher (P<0.05) malondialdehyde level compared with non diabetic erythrocytes. The degree of membrane lipid peroxidation in erythrocytes was significantly correlated with the level of glycosylated hemoglobin. ( r = 0.81, P< 0.05). This suggests that peroxidation of membrane lipids and accumulation of MDA occurs in erythrocytes of diabetic patients.