Sinsitivty AND SPECIFICITY OKMYOGLOBIN IN EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
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Acutemyocardial infarction (AMI) is one ofmajor causes of disa bilityinhumans ail over the world.More than 60%of thedeaths-Occur within the first fewhoursoftheevent (BraunwaldandSobel, 1992). Earlytreatmentwiththrombolytic therapywithin6hours fromtheonset ofAMI has been shownto restoremyocardialbloodflowand reduce moitiality. On the other hand, thrombolytic therapy has its serious side effects ifnot used properly. This necessitates the use of a very specific, sen- skive and rapidlaboratory test for accurate and eariy diagnosis of acute myocardial infarction (Isis et aL 1988). Myoglobin is abeme containingproteinpresent in skeletalmuscles and cardiacmuscle, following acutemyocardial infarctionit is released fromdamaged heartmuscle cells as early as 2 - 3 hours after the onset of chestpain and before the release of creatinephosphokinase (Tuengieretal. 1988). Thisworkwas carried out to evaluate the role ofmyoglobinassayin early diagnosis of acutemyocardial infraction and to compare its speci ficity and sensitivitywith serumcreatine.phosphokinase and electrocardiographic change.