DEVELOPMENT OF ALBINO RAT KNEE JOINT CAVITATION AND THE EFFECT OF CIPROFLOXACIN AND THE POSSIBLE PROTECTIVE ROLE OF VITAMIN E
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Abstract Background: The knee joint cavity starts to develop in the intrauterine life from mesenchymal progenitor at the interzone. Ciprofloxacin is one of fluorinated derivatives of quinolone which has a broad spectrum bactericidal activity. Ciprofloxacin induces damage of the epiphyseal growth plate during early post-natal developmental phase resulting in irreversible bone damage and growth inhibition. Aim of the work: is to study the prenatal and postnatal development of the knee joint cavity in albino rat and detect the effect of ciprofloxacin on the articular cartilage of knee joint and epiphyseal growth plate cartilage of femur and tibia. The study also evaluates the possible protective role of vitamin E It also detects the possible reversible effects of ciprofloxacin after drug stoppage.