SERUM LEVELS OF TISSUE INHIBITOR OF METALLOPROTEINASE (TIMP-1/TIMP-4) RATIO AS A MEASURE FOR ULCERATIVE COLITIS (UC) ACTIVITY.
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This study comprised selection of 30 patients with recurrent episodes of bloody diarrhoea (4-8 stools/day) more than diagnosed previously as UC. Activity Index for UC with a total score of more than 4 indicate disease activity. All patients underwent colonoscopy and routine laboratory investigations. All patients and 30 controls gave fasting venous blood sample for ELISA estimation of TIMP-1.and TIMP-4 serum levels and their ratio was calculated. Results showed that half of patients (15) had active UC with a mean activity score of 8.9±1.5. Pain was the most frequent complaint, followed by frequency of stool/day and the sense of wellbeing. Mean serum levels of TIMP-1 and TIMP-1/TIMP-4 were significantly higher in patients than controls, in males versus females and in patients with active disease than in those with quiescent disease. It was concluded that active UC showed imbalance between serum sensitivity of serum TIMP-1 and specificity of TIMP-4 and could be used for disease severity evaluation.