PLASMA ADIPONECTIN LEVEL AS AN INDEPENDENT PREDICTOR OF EGYPTIAN TYPE 2 DIABETES WITH METABOLIC SYNDROME AND THOSE WITHOUT METABOLIC SYNDROME.
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Background: We aimed to study the plasma adiponectin level as a predictor of Egyptian type 2 diabetes with and without metabolic syndrome. Subjects and methods: This study was carried out on 70 humans divided into three groups . Group I included twenty five type 2 diabetic patients with metabolic syndrome (10 males and 15 females), mean age was (52.9 * 10.5 years). Group II included twenty five diabetic patients without metabolic syndrome (20 males and 5 females), mean age was ( 55.8 ± 9.1 years).Group III included twenty normal health volunteers serving as control (8 males and 12 females),mean age was( 48.8 ± 4.2 years).Thorough history taking and clinical examination was done to all subjects with stress on age of development of DM, duration of DM, line of treatment, waist circumference, BMI, systolic and diastolic BP. The following laboratory investigations were done to all subjects fasting and post prandial blood glucose level, plasma insulin and adiponectin. Result: Plasma adiponectin level was significantly lower in type 2 diabetic patients with metabolic syndrome compared to both type 2 diabetic patients without metabolic syndrome and control group.The study showed a significant negative correlation of adiponectin with body mass index( HMI), waist circumference, systolic and diastolic blood pressure , fasting plasma glucose(FPG) and two hours post— prandial plasma glucose(PPPG), triglyceride(TG), insulin and homeostasis model assessment (HOMA) among group I patients. No significant correlation was elicited between adiponectin level and these parameters in group II neither diabetic patients nor control group. A significant positive correlation was detected between HDL-cholesterol and adiponectin in diabetic patients with metabolic syndrome while no significant correlation was detected between adiponectin and HDL-cholesterol in other groups. .Conclusions: Hypoadiponectinemia can be considered as a cause and a component of metabolic syndrome and it can be considered as a predictor of type 2 diabetes mellitus with metabolic syndrome and not for type 2 diabetes mellitus without metabolic syndrome.