A COMPARATIVE STUDY FOR PLASMA ADIPONECTIN LEVEL IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (TYPE 2 D.M AND HCV)
|Full paper||Not Available|
Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver — related morbidity and is frequently associated with obesity and metabolic syndrome. The recently discovered hormone adiponectin is produced by adipose tissue, and low plasma adiponectin is considered a key factor in the development of the insulin resistance underlying this disease, the aim was to study the level of plasma adiponectin in patients with nonalcoholic fatty liver with type 2 DM, and chronic hepatitis C in comparison with a control group. Design & Methods: The study was conducted on 60 individuals, 37 males & 23 females, their age ranged from 26 to 74 ys, they were categorized into 3 groups: G 1: 20 apparently healthy individuals serving as a control group, 02 : 20 patients with type 2 DM and fatty liver, 03 : 20 patients with chronic hepatitis C and fatty liver. All cases underwent full clinical examination & laboratory investigations, including (CBC), (ESR), liver & kidney — function tests fasting & 2 hours PP blood glucose, lipograms, polymerase chain reaction (PCR) for HCV-RNA in addition to abdominal ultrasonography and estimation of serum adiponectin level by ELISA technique. Results: a significantly decreased plasma adiponectin levels were found in patients with fatty liver disease when compared to the control group. In addition, plasma adiponectin in group 2 (DM) showed significant positive correlation with fasting blood glucose level (r = -52, p <0.05). However plasma adiponectin levels, were significantly lower in group 3 (HCV) than in the other groups. A significant lower adiponectin level was observed in males in all groups. Further more plasma adiponectin in group 3 (HCV) showed significant positive correlation with blood urea (r = 0.48, P <0.05) and HDL level (r = 0.49, P <0.05). Conclusion : plasma adiponectin level is decreased in patients with NAFLD with type 2 DM & chronic HCV and may suggest fat accumulation in the liver.