Oxygen radical activation had been suggested to be involved in
the pathogenesis of hepatocellular damage. They are produced in
conditions characterized by oxidative stress and determine
peroxidation of polypnsaturated fatty acids. Determination of lipid
peroxide products had frequently been used as a measure of oxygen
radical activation. Also, sialic acid (total & lipid-bound) may be
disturbed in inflammation and malignancy. So, the aim of this work
is to study the relationship between lipid peroxides (LP) and lipidbound
sialic acid (LSA), total sialic acid (TSA), a-fetoprotein (ASP)
in patients with liver cirrhosis (LC) and hepatocellular carcinoma
(HCC) and to evaluate LSA & TSA as tumor markers in HCC. The
present study included two groups of patients. The first group
included 20 patients with LC, their age ranged from (40-60) years.
The second group included 20 patients with HCC, their age ranged
from (38-67 years). Thesesroups of patients were compared with 10
healthy individuals (control group), the age and sex were matched
with patient groups. The study showed that, in patients with LC and
HCC, there was a significant (P<0.001) increase of lipid peroxides
(LP), lipid-bound sialic acid (LSA), and total sialic acid (TSA) than
the control group. While serum ASP was significantly (P<0.001)
increased in patients with HCC than the control group. Also, there
was a significant positive correlation between serum LP and LSA
(P<0.01, 1=0.561, & P<0.001, r=0.693, respectively), TSA (P<0.001,
r4.678 & P<0.001, r=0.867, respectively) in patients with LC and
HCC. Moreover, there was a significant positive correlation between
serum LP and APP with HCC. Serum LSA was a more sensitive
biochemical marker (85%) than TSA (70%) and serum AFP (55%), |
