SOLUBLE INTERLEUKIN-2 RECEPTORS 611-20 AND EOSINOPHILS IN PATIENTS WITH BRONCHIAL ASTHMA BEFORE AND AFTER SALBUTAMOL AND ANHYDROUS THEOPHYLLINE THERAPY
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To elucidate the role of T lymphocyte activation and eosinophilic infiltrations in the bronchial tree of patients with bronchial asthma and the effect of salbutamol and anhydrous theophylline on these parameters, a study was carried out on twenty patients having extrinsic asthma (group I), twenty with intrinsic asthma (group II) and ten healthy controls (group III). Soluble Interleukin-2 receptors (sIL-2R), eosinophilic count both in bronchoalveolar lavage (BAL) and blood were performed immediately after the relief of acute attack and one week later during remission. Physiologic parameters including FEVI, FVC and PEFR were also done during acute attack and 20 minutes after inhalation of nebulized salbutamol. Each group of asthmatic patients were divided into two subgroups, group Ia and group Ha received salbutamol and group lb and group lb received anhydrous theophylline. The mean serum and BAL sIL-2R and eosinophilic count were significantly higher in acute episode of asthma compared to normal controls, moreover, there was a positive correlation between sIL-2R and eosinophilic count with an inverse relationship with PEFR. Seven days after the acute attack, patients received salbutamol did not show any significant decrease in either sIL-2R or eosinophilic count in BAL fluid and blood, on the other hand significant Suction was observed in patients receiving anhydrous theophylline. Therefore, it could be concluded that T cell activation with increased eosinophilic infiltration in bronchial tree may lead to enhanced bronchial hyperreactivity in patients with bronchial asthma, anhydrous theophylline possesses antiinflanunatory action by virtue of its inhibitory effect on T lymphocyte activation which might recommend its long term use in asthmatic patients.