THE VALUE OF PLASMA MATRIX METALLOPROTEINASE-1 AND TISSUE INHIBITOR OF IVIETALLOPROTEINASES-1 ESTIMATION AS BIOMARKERS OF ULCERATIVE COLITIS ACTIVITY
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AIM: Overexpression of mucosa( metalloproteinases (MNIP) have been demonstrated recently in inflammatory bowel disease. Their activity can be counterbalanced by the tissue inhibitor of metallo'proteinases (TIM?). The aim of this study was to evaluate the effect of ulcerative colitis (UC) on MMP-1 and TIMP-1 plasma concentrations. as two possible biomarkers of the disease activity. METHODS: MM?-1 and T1MP- I plasma concentrations were measured with an enzyme immunoassay in 16 patients with endoscopically confirmed active UC and 12 healthy controls. RESULTS: Plasma concentrations of both MNIP-1 (13.7+0.2 ng/ ml) and TIMP-1 (799+140 ng / ma were signcantly elevated in UC patients in comparison to healthy controls (11.9+0.9 ng/mL and 220+7 ng/ ml respectively). There was no con-elation between TEMP-1 and MMP-1 concentrations (r=-0.02). TIMP-1 levels revealed significant positive correlations with scored endoscopic degree of mucosal injury. disease activity index and clinical activity index values as well as C-reactive protein concentration. There was no correladon between MMP-1 and laboratory. clinical or endoscopic indices of the disease activity. CONCLUSION: These results confirm the role of both MM?-1 and TIMP-1 in the pathogenesis of ulcerative colitis. However only TIMID- I can be useful as a biomarker of the disease activity, demonstrating as• sociatiort. with clinical endoscopic pictures.