DIPYRIDAMOLE ECHOCARDIOGRAPHY TEST (DET), A NEW TEST TO DIAGNOSE SILENT CORONARY ARTERY DISEASE (CAD) IN DIABETICS
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We studied 60 cases (45 diabetics and 15 normal volunteers as control). For all cases: complete medical history and examination was done, fasting blood sugar, post prandial blood sugar, lipid profile , resting E.C.G, fundoscopy, fluorescence angiography, and D.E.T. in a dose of 0.84 mg/Kg SW in 10 minutes by i.v. infusion were done. Diabetic patients were classified into three groups according to their fundus status (No retinopathy, with background retinopathy, or with proliferative retinopathy). DET was negative in all diabetics with normal fundus while it was positive in 20% of diabetics with background retinopathy and in 66.7% of diabetics with proliferative retinopathy. Diabetics with positive DET had significant higher triglycerides and cholesterol (P< 0.01) and longer duration of diabetes (P <0.01), while no significant difference in either SW or BMI (P> 0.05). We conclude that DET could be considered as a simple screening test for diabetics with silent CAD for the early diagnosis and management of this condition. Routine fundoscopy will be a helpful tool to select the cases which have the priority to be tested by DET.