THE POTENTIAL BENEFICIAL EFFECTS OF PERINDOPRIL OVER CLONIDINE ON DIABETIC NEPHROPATHY IN RATS
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Diabetic nephropathy has become a worldwide epidemic, accounting for approximately one third of all cases of end- stage renal disease. About 30-50% of patients with long-standing diabetes will develop diabetic nephropathy. Improved management of diabetes aimed at improved glycemic control, to avoid initiation of diabetic nephropathy, and antihypertensive treatment blocking the renin-angiotensin system, to avoid its progression and need to be implemented, particularly in high-risk patients. This study was designed to evaluate and compare the reno protective effects of clonidine and perindopril on rats with diabetic nephropathy. Diabetic nephropathy was induced ill rats by streptozotocin (STZ) 100mg/Kg/single LP) administration. Diabetic nephropathy rats were randomly divided into one of 3 groups. Diabetic nephropathy group, clonidine (0.03mg/kg/day) treated group and perindopril (1.5mg/kg/ day) treated group. Each given orally for 4 weeks starting 4 weeks after STZ injection. Systolic and mean arterial blood pressure (SBP & MBP), were measured by rat tail method. Renal blood flow (RBF) were estimated by llowrneter. Fasting blood glucose (FBG) and 24 hours urine albumin were measured by colorimetric methods. Renal tissue specimens were lzistopatholgically examined by hematoxylin & eosin staining. Both drugs significantly reduced SBP, MBE fasting blood glucose (FBG) and urine albumin (mg/24hours). There was insignificant difference between hypotensive effects of clonidine and preindopril. Effects of preindopril on REIF, FBG and urine albumin were more significant than that of clonidine. Moreover, histopathological examination of kidney tissues showed improvement of nephropathy in the form of reduction of basement membrane, thickening and infiltration of the inflammatory cells. From this study we can conclude that, both drugs significantly reduced blood pressure, urine albumin, FCC and RBF with superior effect of perindopril over clonidine.