THE EFFECT OF CALCIUM CHANNEL BLOCKER (AMLODIPINE ) ON PORTAL HYPERTENSION: (EXPERIMENTAL ST
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Portal hypertension is one of the commonest disease in our locality due to prevalence of bilharziasis and the death rate is high from bleeding esophageal varieces due to elevated portal pressure. In the present study we test the effect of amlodipine (a long acting calcium channel blocker of the dihydropyridine group which has no hepatotoxic effect) on the experimentally induced portal hypertension in rabbits. Also, its effects on systemic blood pressure and heart rate were tested. From this study, we found that amlodipine was effective in reducing the elevated portal pressure to normal level in doses which don't produce any effect on the heart rate or systemic blood pressure. We recommend the use of amlodipine in treatment of portal hypertension after necessary clinical studies.