PROTECTIVE EFFECT OF LACIDIPINE ON ISOPRENALINE INDUCED HEART FAILURE AND CYCLOSPORINE INDUCED NEPHROTOXICITY IN RATS
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Lacidipine is a highly vasoselective third- generation calcium channel antagonist that has been shown to produce a sustained reduction in elevated blood pressure, and a low incidence of adverse effects. The present study was carried out to screen the pharmacological effects of lacidipine on isolated rabbit heart and to evaluate the cardioprotective effect of lacidipine on isoprenaline induced heart failure in rats. Also the protective effect of lacidipine on cyclosporine induced nephrotoxicity in rats was studied. Data obtained in the present study pointed out that lacidipine produced significant (P < 0.05) decrease in the basal myocardial contractility of isolated rabbit heart and the negative inotropic effect of lacidipine is much less than that of nifidipine. Also lacidipine has cardioprotective effect on isoprenaline induced heart failure in rats and can effectively antagonize the renal functional and structural changes induced by cyclosporine in rats. These data suggest a new potential for lacidipine in the management of heart failure. Also, we recommend the use of lacidipine for renal transplant patients using cyclosporine for immune suppression to protect their kidneys from cyclosporine induced nephrotoxicity.