THE EFFECT OF LACIDIPINE ON EXPERIMENTALLY INDUCED ATHEROSCLEROSIS IN RABBITS AND ITS ROLE IN L-NAME INDUCED HYPERTENSION IN RATS
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Lacidipine is" a new 1.4 dihydropyridine derivative designed to have -a pOtent vascular selective antagonistic activity. The present study was carried out to screen the pharmacological effects of lacidipine on isolated rabbit aortic strip. Also, the effect of lacidipine on atherosclerosis induced experimentally in, rabbits was studied. Moreover, the effect of lacidipine on LNAME induced hypertension in rats was evaluated. Data obtained in the present study -pointed out that lacidipine produced significant decrease (P < 0.05) in the KCI-induced contraction of isolated rabbit aortic strip. Also, lacidipine antagonized norepinephrine and angiotensin H induced contractions of isolated rabbit aortic strip. Moreover,: lacidipine produced a protective effect on experimentally induced - atherosclerosis in rabbits. Further more, lacidipine exerted antihypertensive and nephroprotective effects'in the model of L-NAME induced hypertension in rats. These results suggests a potentially emerging important role of lacidipine in antagonizing hypertension and renal structural and functional consequences associated with chronic NO synthesis inhibition. So. lacidipine ma) have a promising role in management of many deleterious conditions associated with decreased NO production e.g. cardiomyopathy and stroke.