The renin-angiotensin system plays an important role in the regulation
of cardiovascular, renal, and endocrine functions. Local functional reninangiotensin
systems (RAS) have been demonstrated in many organ and tissue
systems.
It was found that the angiotensin II receptor blockers (ARBs)
suppressed the development of severe arthritis and joint destruction in the
collagen-induced arthritis model. These findings suggest that ARBs may
have therapeutic potential in rheumatoid arthritis.
All animals (30 male rats) were subjected to measurements of the
hind paw thickness and pressure threshold by using analgesymeter.
Subsequently, Freund 's adjuvant was injected into the base of rat-tail. Sixteen
days after administration of Freund 's adjuvant, animals were again subjected
to the previously mentioned tests and were randomly assigned to 3 groups:
I) Control group (7I) candesartan cilextil Treated group (III) celecoxib
treated group
All animals were subjected to the previous tests at days 15,30 after
starting treatment, then all animals were scarified, following scarification,
the stomachs were removed. Gastric contents were collected for evaluation
of biochemical parameters. The stomachs were opened along the greater
curvature and the gastric lesions were evaluated for identifying the ulcer
index.
In this work candesartan cilextil and celecoxib showed significant
beneficial effect (anti-inflammatory and analgesic) compared to arthritic
control non-treated group. |
