EFFECT OF LANSOPRAZOLE ON GASTRO-INTESTINAL MOTILITY, MESENTERIC HEMODYNAMICS AND RENAL FUNCTIONS
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Lansoprazole is widely used nowadays to relieve symptoms and enhance healing of peptic ulcer and reflux oesophagitis. It effectively decreases gastric acid secretion, regardless the primary stimulus, via inhibition of gastric 1-111K+ ATPase (The acid pump). Lansoprazole action on the gastric parietal cells and acid secretion has been extensively studied, however, the effect of lansoprazole on GIT motility and mesenteric haemodynamics remains unclear. The present study was designed to screen the effects of lansoprazole on GIT motility in vivo and in vitro. The effect of its acute and chronic administration on mesenteric blood flow was also determined. To test whether lansoprazole may alter kidney function as some other proton pump inhibitors, changes in renal blood flow, urine flow, pH, Na + and K+ concentrations were also monitored. Our results showed that increasing doses of lansoprazole induced dose related inhibition of rhythmic conraction of rabbit's intestine both in-vitro and in-vivo. Lansoprazole also attenuated ACh induced contraction of rabbit's intestine, histamine induced contraction of Guinea pig ileum and to lesser extent serotonin induced contraction of rat fundus strip. The inhibitory effect of lansoprazole is unlikely to be mediated through adrenergic or dopaminergic receptors as its action was not affected by phentolamine, propranolol or metochloprami de. However, indomethacin was able to attenuate its inhibitory effect indicating the involvement of prostaglandins in mediating lansoprazole effect. Lansoprazole produced insignificant changes in the mesenteric blood flow after both acute and chronic administration. Acute administratioon of lansoprazole in different doses (0.1, 0.3 and 1 gmol/lcg, IV.) induced dose dependent reduction in renal blood flow. It reduced urine flow rate, did not change urine pH, urinary Na+ concentration but it increased urinary K concentration. Its chronic administration (3 urnolikg, IM.) for 4 weeks, caused insignificant change in renal blood flow, reduced urine flow rate, changed urine pH towards the alkaline margin, decreased urinary Na' concentration and increased K' concentration.