EFFECT OF PERINDOPRIL (ANGIOTENSIN CONVERTING ENZYME INHIBITOR) ON VASOCONSTRICTOR ACTIVITY OF HYPERTENSIVE RATS
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In the present study we investigated the possibility that perindopril changes the post synaptic vasoconstrictor activity to a variety of vasoconstrictive agents. Perindopril (10 mg / kg / day) administrated orally to spontaneously hypertensive rat (SHR) for 7 days, significantly reduced the potency and the maximal vasopressor response to phenylephrine (40%) and the maximal response to serotonirt (50%) compared with the responses from vehicle treated STIR. In contrast, perindopril hod no significant effect on the pressor responses to KCL Furthermore, an eguipotent antihypertensive dose of hydralazine (5 mg / lcg / day, per oral for 7 days) exerted no inhibitory effect on the pressor responses elicited by phenylephrine or KCI, but significantly reduced the maximal response to serotonin. The results suggest that 7-days perindopril administration reduced alpha adrenoceptor and -serotonergic receptor- mediated vasoconstriction. However. perindopril did not reduce the vasoconstrictor responses induced by KC1, indicating that those pressor response that are due to depolarization are, in part, independent of angiotensin- converting enzyme inhibition This inhibition of vascular adrenoceptor and -serotonergic receptor pressor activity may underlie, in part, the long-term antihypertensive activity of penindopril in the spontaneously hypertensive rat.