EVALUATION OF MELATONIN EFFICACY IN EXPERIMENTALLY-INDUCED EPILEPSY AND PARKINSONISM
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The pineal gland hormone melatonin has been implicated in so many diversified events from aging to aggression, from hibernation to hypertension, from immunodeficiency to tumor growth and from sleep to stress. The present study was designed to explore the effect of melatonin on experimentally two separate animal models of epilepsy and parkinsonism. It was found that melatonin increased the epilepsy threshold induced by pentylentetrazole (PM) in mice. Melatonin, also, potentiated the anticonvulsant effects of both valproic acid and phenobarbitone. On the other hand, it was found that melatonin enhanced the fiuphenazine- induced parkinsonism in rats. The beneficial effect of the antiparkinsonian drug benztropine was , also, deceased by the concomitant administration of melatonin. The concentrations of acetylcholine, dopamine and GABA were ass yed in the thalamus, hypothalamus and the whole brain of the control group as well as the experimentally two animal models. It was concluded that melatonin has an antiepileptic effect which may be due to its ability to accumulate GABA in the brain, while its deteriorating effect in fluphenazine-induced parkinsonism in rats may be due to deceased dopamine secretion.