Evaluation of Solcoseryl in Experimentally Induced Acute Myocardial Infarction and Renal Function in Rabbits
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Solcoseryl is known to have several antioxidant effects such as inhibition of' superoxide production and hyperperoxidation. It is claimed that solcoseryl exerts a protective effect on the ischeinic myocardium by promoting a rapid recovery from ischemia, probably due to the improvement of oxygen utility through activation of cellular respiration. Solcoseryl also stimulates ATP synthesis, improves glucose transport and promotes angiogenesis. The present study was done to: (I) evaluate the effect of solcoseryl 5mg/kg iv on the mean arterial blood pressure and heart rate of the anesthetized rabbit. (2) investigate the assumed protective effect of solcoseryl on isoprenaline (60p.g/kg i.v)- induced myocardial infarction in rabbits and comparing this effect with that of the calcium channel blocker (verapamil) or the beta-blocker (propranolol). (3) investigate the effect of solcoseryl on the kidney function by measuring blood Na+, K+ urea , creatinine as well as urinary output of Na+, K+ and urine flow. The present study revealed contradictory results with regarding to the claimed beneficial effects of solcoseryl. It was found that solcoseryl injection enhanced isoprenalineinduces myocardial infarction and impaired renal function in rabbits. This dangerous action of solcoseryl could be attributed to its direct effect on the myocardium, hypotension and peripheral vascular pooling of the blood.