Zinc-Metallothionein Provides A Protective Role Against Experimentally Induced Myocardial Infarction And Arrhythmia In Rabbits
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Zinc-metallothionein (MT) is a low molecular weight (MW) zinc binding protein (600-700 Dalton). MT has been proposed to participate in the transport, accumulation, and compartmentation of zinc in the biological system. In addition to its role as a storehouse for zinc, MT acts as a free radical scavenger and protect against cadmium toxicity. The present work aimed to investigate the possible role of MT in providing a myocardial protection against isoprenaline-induced myocardial infarction (MI) and arrhythmias in rabbits. To induce myocardial MT, zinc sulfate was injected intraperitoneally 50mg/kg for. three consecutive days. It was found that MT protected against MI as indicated by the lower levels of creatine kinase-MB, aspertate aminotransferase and lactate dehydrouenase enzymes. It has also potentiated verapamil effect to protect against tachyarrhythmias.