The tetracyclines have properties that appear to modulate host response by
inhibiting the activity of the matrix metalloproteinases (MMP) that cause
collagen destruction, regulating angiogenesis, inhibiting the activity of
mammalian collagenases and gelatinases, and antioxidant activity. The
previously mentioned parameters are essential in pathogenesis of rheumatoid
arthritise. The aim of this work is to evaluate the possible therapeutic effect of
doxycyclin in Freund's adjuvant-induced arthritis and its safety in comparison
with CO)C2 selective inhibitors, celecoxib.The anti inflammatory and analgesic
efficacy was demonstrated using paw edema test and Analgesymeter. The safety
was demonstrated using the ulcer index and the aggressive factors (volume of
gastric secretion, titrable acidity, peptic activity) as well as protective factor
(mucin) involved in gastric ulcer pathogenesis. The results demonstrated that
although doxycyclin produced statistically significant improvement in
rheumatoid arthritise but this effect was delayed and less than that of celeccocib.
Doxycyclin proved to be safe on stomach. Although celecoxib increase volume
of gastric secretion, titrable acidity, peptic activity and decreased mucin, the ulcer
index induced by it was insignificant .In conclusion, doxycyclin is an effective
alternative of Cox2 inhibitor in rheumatoid arthritis with more safety profile. This
results needs to be investigated clinically.
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