Effect of doxycyclin in Freund's adjuvant-induced arthritis in albino rats
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The tetracyclines have properties that appear to modulate host response by inhibiting the activity of the matrix metalloproteinases (MMP) that cause collagen destruction, regulating angiogenesis, inhibiting the activity of mammalian collagenases and gelatinases, and antioxidant activity. The previously mentioned parameters are essential in pathogenesis of rheumatoid arthritise. The aim of this work is to evaluate the possible therapeutic effect of doxycyclin in Freund's adjuvant-induced arthritis and its safety in comparison with CO)C2 selective inhibitors, celecoxib.The anti inflammatory and analgesic efficacy was demonstrated using paw edema test and Analgesymeter. The safety was demonstrated using the ulcer index and the aggressive factors (volume of gastric secretion, titrable acidity, peptic activity) as well as protective factor (mucin) involved in gastric ulcer pathogenesis. The results demonstrated that although doxycyclin produced statistically significant improvement in rheumatoid arthritise but this effect was delayed and less than that of celeccocib. Doxycyclin proved to be safe on stomach. Although celecoxib increase volume of gastric secretion, titrable acidity, peptic activity and decreased mucin, the ulcer index induced by it was insignificant .In conclusion, doxycyclin is an effective alternative of Cox2 inhibitor in rheumatoid arthritis with more safety profile. This results needs to be investigated clinically.