CARDIOVASCULAR PROTECTIVE EFFECT OF KETANSERIN ON ACUTE MYOCARDIAL INFARCTION AND HYPERTENSION IN RATS
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In this study, cardiovascular effects of ketanserin (5HT2 antagonist) on hypertension ( induced by left renal artery ligation in rats) and on acute myocardial infarction (induced by S.0 injection of isoprenaline in rats) were studied. From the results of this study, it was found that ketanserin at dose 0.5- 3 mg/kg IV had dose dependent significant antihypertensive effect in rats. Also, ketanserin ( 0.5 mg/ 100 g I.V . ) had cadioprotective effect on acute myocardial infarction in rats as ketanserin decreased significantly the elevation of T wave in E.C.G and decreased significantly the elevation of serum CPK and LDH compared to control group . In addition, ketanserin had reduced pathological changes in infarct cardiac tissue in rats . These effects of ketanserin may be due to 5 HT2 blockade and cct adrenergic blockade which lead to Vasodilation, inhibition of platelet aggregation and improvement of cardiac ischaemia .