EFFECT OF CHRONIC OMEPRAZOLE ADMINISTRATION ON RENAL VASCULAR REACTIVITY AND TUBULAR EXCRETION OF THE RAT
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Omeprazole is widely used in the treatment of the gastroesophageal ref lux and peptic ulcer diseases. It inhibits the proton pump in the gastric parietal cells. Proton pumps also exist in kidney nephron. However, the renal effects of omeprazole have not been elucidated yet. This study investigates the effects of omeprazole intramuscular administration for four weeks on mean arterial pressure (MAP), renal blood flow (RBF), renal vascular reactivity to both phenylephrine (PHE1 and dopamine (DA) and on tubular excretion. Kidneys were also examined for histopathological changes. The study included four groups of rat (n=6), the second and the fourth served as control and were injected with the vehicle for 4 weeks. The first and the third were inejcted with omeprazole (0.2 mg/kg) for the same time period. Chronic omeprazole administration slightly reduced P.BF (from 12.1 + 0.3 to 11.2 + 0.4 ml/min) but significantly reduced the responsNeness of the renal vasculature to the vasoconstrictor PEE and the vasodilator DA. Urinary pH was increased (6.8 to 7.6) and urine flow rate was slightly decreased (from 50+6 to 38+5 tit/min). Na.- and K excretion was impaired (from 110+11 to 72+9 mmol/min for Na+ and from 69+6 to 47+7 mmol/min for K+). Albumin traces were (-fleeted in urine. Histopathological examination 'i.owed evidence of interstitial nephritis. Thus chronic use of omeprazole may be associated • fth renal damage and impaired kidney functions.