The Gastro-protective Effect of Transdermal Nitroglycerin and it s Underlying Mechanisms in Ethanol Induced Gastric Ulcer in Rats
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Backeround: Nitric oxide donors proved to have gastro-protective effect experimentally but the clinical applicability of this effect is limited by pharmaceutical nature of these drugs. Transdermal nitroglycerine adhesive patches (TNAP) is a safe clinically used preparation provide a continuous administration NO with constant rate. .The aim of this study is to evaluate the gastro-protective effect of (TNAP) on ethanol- induced gastric ulcer in rats and the possible underlying mechanisms. Methods and results: TNAP caused significant improvement in ethanol (90%) induced gastric ulcers in rats. This improvement is represented by significant reduction of ulcer index (56%), volume of gastric secretion (40%), liftable acidity (67%), peptic activity (62%), mucin concentration in gastric secretion (36%) and vascular permeability expressed as jig Evan's blue/g. tissue (47.6%) compared with rats received 1 ml/rat ethanol P.O. Conclusion: TNAP release 20-25 pg/cm2/h for 2 hours (400-500 pg/ rat as surface area of TTS-5 used in this work is 10 cm2) proved to have gastroprotective effect against ethanol 90% (Topical acute injury). This gastroprotective may be mediated by reduction of acid secretion and peptic activity, reversal of ethanol induced inhibition of mucin binding protein and vascular damage.