Backeround: Nitric oxide donors proved to have gastro-protective effect
experimentally but the clinical applicability of this effect is limited by
pharmaceutical nature of these drugs. Transdermal nitroglycerine adhesive
patches (TNAP) is a safe clinically used preparation provide a continuous
administration NO with constant rate. .The aim of this study is to evaluate the
gastro-protective effect of (TNAP) on ethanol- induced gastric ulcer in rats
and the possible underlying mechanisms.
Methods and results: TNAP caused significant improvement in ethanol
(90%) induced gastric ulcers in rats. This improvement is represented by
significant reduction of ulcer index (56%), volume of gastric secretion
(40%), liftable acidity (67%), peptic activity (62%), mucin concentration in
gastric secretion (36%) and vascular permeability expressed as jig Evan's
blue/g. tissue (47.6%) compared with rats received 1 ml/rat ethanol P.O.
Conclusion: TNAP release 20-25 pg/cm2/h for 2 hours (400-500 pg/ rat as
surface area of TTS-5 used in this work is 10 cm2) proved to have gastroprotective
effect against ethanol 90% (Topical acute injury). This gastroprotective
may be mediated by reduction of acid secretion and peptic activity, reversal of ethanol induced inhibition of mucin binding protein and
vascular damage. |
