EFFICACY OF TWO DIFFERNT DOSE LEVELS OF OFLOXACIN IN DRUG RESISTANT CASES OF ENTERIC FEVER.
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The present study was designed to investigate the effects of two different oral dose levelS of offoxacin in two groups of drug-resistant cases of enteric fever. Thirty nine cases were selected from patients admitted at Benha Fever Hospital. All of whom had been febrile for 10-16 days with positive Widal test and blood cultures for salmonella and not responding to chloramphenicol, trimcthoprim - sulfamethozazole and ampicillin. The 1st. group 21 (patients), received 600 mg. of offoxacin daily for 8 days while the 2nd. group (18 patients). received 400 mg. daily for the same period The age, duration of signs, symptoms, laboratory results and severity of illness were not significantly different in the two groups. Clinical assessments and laboratory tests were conducted on each patients before, during and after termination of treatment. The findings revealed that all patients in both groups responded quickly, fever subsided to 37°C within a mean of 13 day in the 1st. group and 4.3 days in the 2nd. group. The bacterial elimination rate was 100% at the termination of therapy in both groups as well as after 3 and 5 weeks later. No relapse occurred and all stool cultures were negative. Side effects were recorded in 3 cases (7.6%). Two patients had mild epigasvic upset (5.1%0 and one patient had mild skin rash (2%). In conclusion the data revealed that ofloxacin is a safe, effective and welltolerated therapy in the treatment of cases of enteric fever, especially those caused by resistant strains, with a quick response and practically with negligible relapse rate. Moreover, the findings showed no proven superiority of the bigger dose level over the small one.