EFFECT OF SOME BETA ADRENERGIC BLOCKERS ON 00GENESIS
|Full paper||Not Available|
The effect of adrenergic blockade on oogenesis and maturation of graafian follicles in female albino nts NILS investigated. Subcutaneous injection of propranolof (non selectit e, cross blood brain barrier) In a dose of 3 mg /kg/ dav for caused 4 weeks insignificant changes in the average num ber of growing and mature graafian follicles in animals sacrificed at proestrous. Also, the same dose of propranolol for the same duration caused insignificant changes in the average number of growing crag- Lan follicles and corpora lutea in the animals sacrificed at metestrous. Subcutaneous injection of propranolol in a dose of 5 rug /kg/ day for 8 ueeks. caused significant reduction (P <0.0$) in the average number of growing graafian follicles and corpora lutea in animals sacrificed at metestrous. Nadolol (non selective, doesn't pass blood brain barrier') In equipotent dose to s mg acgt propranoloi (53 mg fkg) KU Injected subcutaneously daily for 8 weeks also caused reduction (P <0.(15) on the 10 enge number of growing graaftan follicles Enticed at melestrous. Metoprolot lSelectise beta, and corvette lUtta in the animals sacrificed in equipotent dose to 5 mglkg propranolol blocker, doesn't pass blood brain barrier) nvglicg) w as injected subcotancoush dall for % meeks caused Insignificant thane 0, > 0.05) on the average number of growing graaftan tollicks and corpora lutea in the animals sacrificed at metestrous. Propranolol (Smg/kg) and Nadolol (5.5 mg /kg) injected subcutaneously daily for 8 weeks caused no effect on ovulation Induced by pregnant mare serum gonadotrophin. The effect of propranolol in a dose of Smg /kg/ day for 8 %4 in the animals kept without administration for 4 weeks more. eels was reversed The above results suggested that propranolol and nadolol caused significant reduction in the process of oogenesis and ovulation. Metoprolol caused insignificant effect.