STUDY ON THE EFFECT OF SERTRALINE ON THE HISTOGENESIS AND DEVELOPMENT OF THE KIDNEY OF RAT EMBRYO
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This work aimed to evaluate the effect of sertraline, as an antidepressant agent, on the histogenesis and development of kidney of embryo in female pregnant rats. Pregnant female albino rats were adminstered 5mg/kg /day sertraline intraperitonially starting on 2nd of gestation till the day llth for ten doses.The control group received saline by the same way and the same duration of treated group.At the days 12 and 18 the kidney of embryos of both groups were assessed morphologically and histologically. The kidney of treated embryos showed growth retardation,less differentiation and necrosis in both ages with variable degrees. Retardation of growth indicated by decrease in number of renal corpuscles and renal tubules. Proximal and distal connvoluted tubules were not completely differentiated with cystic dilatation of some of them mainly at 18 days. Their was loss of normal pattern of renal corpuscles with dilatation of their capillary tufts. Necrosis was observed in the cells of renal tubules and mesenchymal cells. These results suggest that the use of sertraline as antidepressant agent during childbearing period may affect the morphological and histological development of renal structure of the embryo. So, the results recommend to potentially avoid the use of this medication during gestation.