CYTOPROTECTIVE AND FUNCTION MODULATOR EFFECTS OF GARLIC (ALLIUM SATIVUM I.)
|Full paper||Not Available|
The present work aimed to clarify and investigate the beneficial or toxic effects of aqueous garlic extract (AGE) on haematological and biochemical parameters as well as histological structure of both the liver and kidney. Sixteen normal male albino rats weighing (300-370g) were divided into two equal groups. The first gourp did not take any medication and used as a control. The second one received AGE in a dose of 600mg/kg/day intragastrically as a single dose for 28 days. Haematolgically, the garlic extract improved blood parameters and haemoglobin level. Biochemically, the extract induced hypoglycaemic, hypolipidaemic effects and improved liver and kidney function related parameters. Microscopic examination of the liver of garlic-treated rats revealed hepatocytes with less cytoplasmic vacuolation and more vesicular nuclei, dilated blood sinusoids and arterioles with increase in Von Kupffer cells. There was an increase In acidic mucopolysaccharides mainly around of bile duct and the wall of arterioles. While the kidney showed renal tubules with acidophilic cytoplasm and vesicular nuclei. There was hyperplasia of mesangeal cells of the glomeruli with a slight decrease in collagenous fibres and an increase of acidic and neutral mucopolysaccharides mainly in renal tubules, blood vessels and basement membrane.These results suggesed that aqueous garlic extract improves various haematological and biochemical parameters as well as it gives a cytoprotective effect to the tissues of liver and kidney.