HISTOLOGICAL STUDIES ON TIIE EFFECTS OF FELBAMATE ON THE RESPIRATORY SYSTEM OF NEONATE ALBINO RATS
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The goal of epilepsy treatment is complete seizures control with minimal adverse drug reactions. The objective of this work was to evaluate the effect of long exposure to felbamate, anticovulsant drug, on the histological structure of tracheal and lung tissues of young (neonate) rats.This study could be attributed in understading of the cau§es which precipitate the upper respiratory tract infections in felbamate-treated patients. The results of the present work showed that felbamate induced marked degenerative changes, haemorrhagic fluid accummulation and cellular infiltration in the tracheal and lung tissues of treated rats after 45 days. Most of previous changes were resolved after 15 days of felbamate withdrawal. The results were discussed on the light of the literature's data. The findings may be supported the suggestion that direct toxic and/or immune-mediated effects may contribute to the observed degenerative and haemorrhagic effects of felbamate in the tracheal and lung tissues in the present study. In conclusion, all epileptic cases which are on felbamate as a monotherapy should be reviewed carefully to promote drug withdawal when necessary. In addition, blood count monitoring and pulmonary function evaluation during felbamate treatment is recommended.