THE PROTECTIVE EFFECT OF L•ARGENINE ON INFARCTION INDUCED IN RATS
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The cardioprotective effect of L-argenine was assessed on myocardial infarction induced in rats by ligation of left coronary artery. The degree of protection was determined biochemically by measuring level of serum creatine phosphokinase enzyme (CPK) and histopathologically, by estimating the percentage of infarct size (I.S.%). In addition, the injury current in E.C.G. tracing were studied. In rats pretreated with L-argenine (60 mg/ kg/I.P.) 15 min. before induction of infarction, serum CPK & I.S. % were significantly decreased compared with infarcted non-treated rats (P <0.01), similarly, treatment of rats with L-argenine, 15 min. after induction of infarction significantly decreased, the serum CPK and I.S. % compared with either infarcted non treated or pretreated rats (P < 0.01). Moreover, the injury currents, which were observed in the ECG were improved. In conclusion, L-argenine could protect the heart against extension of infarct size and the protection was more evident in post rather than preinfarction administration of L-argenine.