EFFECT OF MOXONIDINE ON BLOOD PRESSURE, LIPID PROFILE, RENAL AND HEPATIC HEMODYNAMIC IN HYPERTENSIVE HYPERCHOLESTEROLEMIC RATS
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In the present study, moxonidine, an I I-a2 receptor agonist, produced concentration ii related contraction of the rabbitis aortic spiral strips. This contractile effect of moxonidine was significantly antagonized by yohimbine, but not to the same extent by praz,osin. Chronic moxonidine treatment of DOCASalt hypertensive hyper-cholesterolemic rats induced significant reduction of blood pressure and heart rate, in addition, it produced a significant decrease in total cholesterol, triglyceridies and LDL-cholesterol levels. Moxonidine treatment resulted in a significant decrease in serum sodium with no change in serum potassium and serum creatinine in hypertensive hypercholesterolemic rats. Moxonidine favourably affected renal and hepatic hemodynamic parameters in both hypertensive and normotensive rats. Moreover it improved the histopathological picture of the liver and exhibited a renoprotective effect appeared in the form of increasing renal blood flow velocity with improvement of glomerulosclerosis.