EVALUATION OF MELATONIN EFFICACY IN EXPERIMENTALLY-INDUCED EPILEPSY AND PARKINSONISM IN RATS
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The pineal gland hormone melatonin has been implicated in so many diversified events from aging to aggression, from hibernation to hypertension, from immunodeficiency to tumor growth, and from sleep to stress. The present study was designed to explore the effect of melatonin on experimentally two separate animal models of epilepsy and parkinsonism. It was found that melatonin increased the epilepsy threshold induced by pentylenetetrazole (PTZ) in mice. Melatonin also potentiated the anticonvulsant effects of both Valproic acid and phenobarbitone. On the other hand, it was found that melatonin enhanced the Fluphenazine-induced Parkinsonism in rats. The beneficial effect of the antiparkinsonian drug Benztropine was also decreased by the concomitant administration of melatonin. The concentrations of acetylcholine, dopamine and GABA were assayed in the thalamus, hypothalamus, and whole brain of the control group as well as in the experimentally two animal models. It was concluded that melatonin has an ant/epileptic effect which may be due to its ability to accumulate GABA in the brain, while its deteriorating effect in Fluphenazine-induced Parkinsonism in rats may be due to decreased dopamine secretion.