PROTECTIVE AND CURATIVE EFFECT OF ISRADIPINE AND LISINOPRIL AGAINST PROGRESSION OF RENAL FAILURE IN RATS
|Full paper||Not Available|
This work was done to evaluate the possible beneficial effects of the calcium channel blocker ( isradipine ) and the Angiotensin - Converting enzyme inhibitor (ACEls ) ( lisinopril ) on acute renal failure ( ARF ) induced by dehydration and glycerol in male albino rats either prophylactically or curatively. Animals were classified into 7 groups, each has 10 animals: normal control group, uremic prophylactic control group, uremic curative control group, uremic treated with lisinopril prophylactically group, uremic treated with lisinopril curatively group, uremic treated with isradipine prophylactically group and uremic treated with isradipine curatively group. The results of this work indicate the ability of isradipine to improve the biochemical parameters ( urea, creatinine, sodium, potassium and calcium) and histopathological parameters of acute uremic rats both prophylactically and curatively while lisinopril failed to do that effect. The above results suggest the possibility of using isradipine in treatment of acute renal failure or as a prophylactic when acute renal failure is predicted.