Publications of Faculty of Medicine:Hyperbaric Oxygen: Silver Bullet for Diabetic Foot Ulcers: Abstract

Hyperbaric Oxygen: Silver Bullet for Diabetic Foot Ulcers
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Background: Hyperbaric Oxygen Therapy (HBOT) involves the administration of pure oxygen under high pressure conditions. HBOT is used as an adjuvant therapy for a variety of conditions; including chronic wounds, infections, stroke, tissue transplantation, anemia, cancer management, skin flaps & grafts, CO poisoning, air or gas embolism, decompression thickness, necrotizing fasditis, crush injury, compartment syndrome, gas gangrene and autism. Objective: This prospective study was designed to evaluate the efficacy of HBOT as adjuvant treatment for I diabetic foot ulcers in comparison to the conventional treatment. Patients and methods: This study comprised 82 diabetic patients, aged 38 to 72 years. Patients were randomized into two groups: Group A assigned to receive HBOT in combination with conventional wound care & group B received conventional wound care only for the treatment of diabetic foot ulcers. Outcomes were measured every week for 111 two months during the treatment period and then at three-month intervals for one year. Ulcers were graded using Wagner classification system. Both groups were compared as regards healing time, need of amputation, quality of life. Results: The demographic characteristics of the 82 patients were 28 women (34%) and 54 men (65.9%), age I wraans g3e.5 f rcomm2 3. 2T thoe 7re2 wyeaasr sn.o Tnh-sei gmneifidciaannt udlcifefer rdeunrcaeti obne tfwore ebont hb ogtrho ugprosu wpas sa 7s. 2re mgaorndt hdse, manodg rtahpeh mice cdhiaanra ucltceerris atircesa. Complete healing of the index ulcer was significantly faster in hyperbaric group 50% in comparison to 29% in group B. 2 major amputation were performed in HBOT group as compared to 3 cases in group B; all of them were Wagner grade IV. Five minor amputations were performed in each group during the 1st year of follow up. 63% of group A were , satisfied as regard the management of their ulcers in comparison to 41% in group B.