PROSPECTIVE RANDOMIZED STUDY EVALUATING THE REDUCTION OF POST SURGICAL ADHESIONS BY INTRAOPERATIVE APPLICATION OF ADHESION PREVENTION SOLUTION
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The objective of this study was to assess the safety and to make a preliminary assessment of the efficacy of 0.5 % ferric hyaluronate adhesion prevention gel in reducing the incidence severity, and extent of adhesion formation at sites without direct surgical trauma or adhesiolysis at the time of surgical laparotomy. A second look laparoscopy was performed to assess the adhesions. Twenty seven patients aged 24-41 years received 300 ml 0.5 % ferric hyaluronate adhesion prevention gel or lactated Ringer's solution as an intraperitoneal instillate at the completion of the laparotomy procedure. A planned second- look laparoscopy, 8-12 weeks after the laparotomy was performed to evaluate the presence of adhesions. All patients tolerated the procedure and did not manifest any serious adverse events. There was one patient developed minor intestinal leak that closed spontaneously after 3 weeks. At second look laparoscopy, patients treated with 0.5 %Jerrie hyaluronate adhesion prevention gel had significantly fewer adhesions than control patients When adhesions did form, they were sigrfificantly less extensive and less severe in patients who received 0.5 % ferric hyaluronate adhesion prevention gel. In conclusion 0.5 96 ferric hyaluronate adhesion prevention solution was safe and highly efficacious in reduction of the number, severity, and ex-tent of adhesions throughout the entire abdomen following surgical laparotomy.