Objectives: This prospective multicenter study was conducted to evaluate the outcome of
patients with lower extremity soft tissue sarcoma (STS) treated with functional limb-salvage
surgery (FT SS) with adjuvant radiotherapy (RT), defined as the 5-year local recurrence free
rate (LRFR), distant metastasis free rate (DMFR), local recurrence/ distant metastasis free
rate (LR/ DMFR) and survival rate (SR).
Patients & Methods: Treatment strategy was functional compartmental resection that
emphases wide surgical excision with a preservation of at least one innervated muscle in a
compartment to improve functional outcome combined with adjuvant postoperative RT.
Excised specimens were examined histopathologically for evaluation of the surgically
defined margin as free histological margin; positive microscopic resection margin was
defined as tumor cells present at or within 1 mm of the inked margins of resection.
Complications were assessed in terms of significant wound complication, bone fracture, and
peripheral nerve damage. The study included 26 patients; 14 females and 12 males with
mean age of 46.9±16 years. |
