Functional Limb-Salvage Surgery with Postoperative Radiotherapy as a Treatment Strategy for Adult Soft Tissue Sarcoma of the Lower Extremity
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Objectives: This prospective multicenter study was conducted to evaluate the outcome of patients with lower extremity soft tissue sarcoma (STS) treated with functional limb-salvage surgery (FT SS) with adjuvant radiotherapy (RT), defined as the 5-year local recurrence free rate (LRFR), distant metastasis free rate (DMFR), local recurrence/ distant metastasis free rate (LR/ DMFR) and survival rate (SR). Patients & Methods: Treatment strategy was functional compartmental resection that emphases wide surgical excision with a preservation of at least one innervated muscle in a compartment to improve functional outcome combined with adjuvant postoperative RT. Excised specimens were examined histopathologically for evaluation of the surgically defined margin as free histological margin; positive microscopic resection margin was defined as tumor cells present at or within 1 mm of the inked margins of resection. Complications were assessed in terms of significant wound complication, bone fracture, and peripheral nerve damage. The study included 26 patients; 14 females and 12 males with mean age of 46.9±16 years.