Publications of Faculty of Medicine:Impact of laparoscopic sleeve gastrectomy on obesity-associated co-morbidities: A two-year follow-up prospective study: Abstract

Impact of laparoscopic sleeve gastrectomy on obesity-associated co-morbidities: A two-year follow-up prospective study
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Objectives: To determine the effects imposed by laparoscopic sleeve gastrectomy (LSG) on obesity-associated co-morbidities. Patients & methods: The study included 40 patients; 13 morbid obese and 27 obese patients. All patients were evaluated preoperatively for existence and severity of co-morbidities and determination ofHomeostasis Model Assessment of Insulin Resistance (HOMA-IR). All patients underwent LSG; operative time, hospital stay, and intraoperative and postoperative (PO) complications were registered. Postoperative monitoring included evaluation of the percentage of excess weight loss (%EWL)and the percentage of excess body mass index loss (%EBMIL) at 3, 6, 12 and 24 months after surgery; the frequency of associated co-morbidities and HOMAIR index was evaluated at 6, 12 and 24 months after surgery. Results: Mean operative time was 157.817 minutes and mean duration of hospital stay was 5.50.9 days. No conversion to open surgery. All patients showed progressive weight loss throughout the follow-up period with progressively increasing %EWL and %EBMIL. BMIstrata showed significant progressive change throughout follow-up period; 27 women were overweight and only 13 women were obese. All obesity-associated co-morbidities showed progressive improvement or resolution. At end off ollow-up, 7 patients still had co-morbidities, 9 patients had improved co-morbidities and 24 patients had resolved co-morbidities with an improvement and resolution rates of 22.5% and 60%, respectively and only 11 co-morbidities were recorded at end off ollow-up in various combinations in the 7 non-responders. Preoperatively, all patients were insulin resistant; however, at the end off ollow-up period HOMA-IR index of all patients was within the non-resistant range. Conclusion: Bariatric surgery effectively improves obesity-associated co-morbidities and could be considered as non-pharmacological therapeutic modality for these co-morbidities. Laparoscopic gastric sleeve is a safe and effective appropriate surgical procedure for morbidly obese patients with associated co-morbidities.