Publications of Faculty of Medicine:Short-Term Outcome Of D1 Versus D2 Gastrectomy For Gastric Cancer Patients: Abstract

Short-Term Outcome Of D1 Versus D2 Gastrectomy For Gastric Cancer Patients
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Objectives : The present work aimed to evaluate short-term outcome of subtotal gastrectomy with D1 versus 02 lymphadeizectorny (LND) as a therapeutic modality for distal gastric carcinoma. Patients &Methods : The study included 35 patients; 25 males and 10 females with mean age of 66±11.4 years and had biopsy-confirmed distal gastric adenocarcinoma and assigned for gastrectomy. The extent of resection was determined by tumor site, tumor stage, and growth pattern according to the Lauren classification. Subtotal gastrectomy was performed with Billroth 11 technique for reconstruction. Lymph node dissection was conducted and extirpation of >25 lymph nodes was classified as an extended (D2) LND and extirpation of <25 lymph nodes was defined as a standard (DI) LND. Surgical morbidity or mortality rate was defined as any complication or deaths occurring in the 30-day postoperative (PO) period were reported. Results I D1 LND was performed in 21 patients and 02 LND in 14 patients with a mean total number of extirpated lymph nodes of 28.1±16; range: 5-62 LW. Histopathological examination of extirpated LW detected metastasis in 143 LW out of the 983 excised LW with a total metastasis ratio of 0.15. Mean metastasis ratio was significantly higher with 02 versus D1 LND. Three patients had gastrectomy plus splenectorny and 4 patients had gastrectomy plus pancreaticosplenectomy with a significant increase of the frequency of the need for extensive surgery with D2 LND. Mean duration of surgenj was significantly longer and intraoperative blood loss was significantly higher in D2 laND compared to D1 LND. Postoperative morbidity was recorded in 10 patients (28.6%) and 6 patients (17.1%) died with significantly higher frequency of PO morbidity and mortality with 02 LND compared to D1 LND. There was a positive significant correlation between occurrence of PO morbidity and lesion size, number of excised LN, nietastatic LW, intraoperative blood loss, operative time and hospital stay. However, there was a positive significant correlation between PC) mortality and number of metastatic LW, metastatic ratio, intraoperative blood loss and operative time. Multi-variate regression analysis defined number of excised LN as a significant independent factor for PO morbidity and metastatic ratio of LW as a significant independent factor for PO mortality. Using ROC analysis, number of excised LW was defined as the specific predictor for, occurrence of PO morbidity with area under curve (AUC) =0.824 and defined the metastatic ratio as specifit predictor for PO mortality (AUC=0.871). Conclusion : It could be concluded that subtotal gastrectomy with D1 lymphadenectomy is appropriate surgical modality for ptitierits with gastric carcinoma with significantly lower intraoperative and shot-term postoperative morbidity and mortalihj compared to 02 lymphadenectomy.