Abstract
Background: The adriamycin is an antineoplastic drug used for
treatment of various types of cancer. The drug is embryotoxic and
teratogenic in rats.
The aim of this work : was to confirm the teratogenic effects and
the histopathological changes in the abdominopelvic region of the fetal
rats following the administration of adriamycin in the pregnant
rats.
Material and Methods: Eight pregnant rats were divided into
two equal groups:
The control group and the adriamycin group. In the control group,
the pregnant rats were injected intraperitoneally with a saline at a dose
of 2m1 /kg B.W once daily from the 6th to the 9th day of gestation. In
the adriamycin group, the pregnant rats were injected intraperitoneally
with adriamycin at a dose of 4mg /kg 8. W. once daily from the 6th to
the 90 day of gestation .0n the 20th day of gestation, the pregnant rats
underwent cesarean sections .The number of fetuses and their weights
were recorded. The abdominopelvic region of the fetuses were examined
by the dissecting microscope to discover any congenital anomalies in
the gastrointestinal and the genitourinary systems. Two fetuses from
each pregnant rats were selected randomly for serial sections and histopathological
examination. |
